Diarrhea is one of
the most important problems in show pigs. It can occur at any
time, from first obtaining a show pig through the last day of
exhibition. It can become a chronic condition that persists for
weeks. Diarrhea can be caused by nutrition, infectious diseases,
internal parasites, or a combination of these.
Dietary Causes
Nutritional causes are relatively easy to
detect and correct. Show pigs are typically fed high protein rations to
develop maximum muscling. Overfeeding protein can, in itself, cause
loose stools or diarrhea. If a pig is growing well but has a chronically
loose stool, reduce the protein and/or increase fiber in the diet. If
the stool does not firm up, there are probably other causes of diarrhea.
Parasitic Causes
Whipworms
are a major cause of diarrheal disease in show pigs. Infection occurs
after pigs ingest microscopic whipworm eggs while rooting or eating in a
contaminated environment. Whipworm eggs remain viable for as long as six
years so contaminated premises are an important source of infection.
Whipworms cause inflammation of the cecum and spiral colon, resulting in
loose stools or diarrhea between three to seven weeks after ingestion of
eggs. Dark stools containing blood can occur. Untreated whipworm
infection causes a chronic wasting disease that lasts for several weeks
to months. Infected pigs have a loose or diarrheic stool, and “rail out”
or become extremely emaciated. Death can occur or pigs can become
chronic poor performers. Swine whipworms are not important as a human
disease.
Cryptosporidium spp protozoa rarely cause inapparent infection
or mild diarrhea in swine. Cryptosporidiosis in humans primarily occurs
after ingestion of water or food contaminated with human-type C.
parvum. This is discussed in the Texas Agricultural Extension
Service fact sheet L-5162, “Human Cryptosporidium and
Cryptosporidiosis.”
Giardia spp protozoal infection in swine is rare, but it does
cause disease in humans. Contaminated water is the main source of
Giardia spp.
Bacterial Causes
Swine dysentery
or “bloody dysentery” from infection with Brachyspira (Serpulina)
hyodysenteriae is a major cause of diarrheal disease in show pigs.
Pigs can be exposed to the organism from the feces of recovered carrier
pigs or from contaminated premises, trailers, or scales. Pigs affected
with this disease usually become very sick. This organism infects the
cells lining the cecum and spiral colon (the same area as whipworms) and
prevents reabsorption of fluids. Affected pigs severely dehydrate and up
to 30% can die. Most affected pigs will drink but will not eat. Pigs
that recover are intermittent shedders of B. hyodysenteriae and
are a source of infection for clean pigs. Swine dysentery bacteria are
not known to cause disease in humans.
Salmonella typhimurium infection is another important cause of
diarrheal disease in show pigs. They become infected by exposure to
contaminated swine manure on premises, trailers, or scales. Chronic
diarrhea persists until effective treatment is administered. Death can
occur in untreated animals.
Salmonella choleraesuis infection also is very important in
swine. It causes only a transient or short-term diarrhea followed by
systemic or blood stream infection. Affected pigs are very sick and can
die or become chronic poor performers if not promptly diagnosed and
treated. Both S. typhimurium and S. choleraesuis are
called host-adapted salmonella because they cause sickness in swine.
Fecal contamination from other livestock, wild animals (including
rodents, reptiles, and amphibians), pets, and birds also can contain
many species of salmonella. There are more than 2,200 known species that
can cause infection in swine but not obvious disease (called nonhost-adapted
salmonella). Swine that become infected with nonhost-adapted salmonella
shed these bacteria in the feces primarily within the first two weeks
after exposure. Regardless of the source of salmonella, if humans ingest
a host-adapted or nonhost-adapted type from their own contaminated skin,
clothing, equipment, or food, sickness can occur.
Ileitis is an important postweaning disease of swine, especially in
commercial operations that supply pork (non-show pig operations). This
disease causes a range of problems from sudden death to chronic diarrhea
that reduces the rate of gain. Lawsonia intracellularis is the
causative bacterium. Though it is rarely the cause of diarrheal disease
in show swine, veterinarians consider this organism as a potential cause
when making a differential diagnosis. L. intracellularis does not
cause human disease.
Viral Causes
Transmissible gastroenteritis
(TGE) virus
causes vomiting and profuse watery diarrhea after exposure to
contaminated swine manure. Fecal exposure to TGE virus can be directly
from sick pigs with diarrhea or indirectly from contaminated footwear or
bird migration from one swine farm to another. The seasonal peak for TGE
infection of swine is winter, when bird migrations occur. The incubation
period for TGE is only 18 to 36 hours. This means that pigs taken to
prospect shows on a weekend can be affected with TGE disease signs by
the following Monday. TGE causes extreme loss of condition in show pigs
weighing from 25 to 280 pounds. Two weeks or more are necessary for full
recovery. As many as 100% of unweaned pigs can die from the disease, but
death rarely occurs in animals above 25 pounds or older than five weeks
of age. Pigs that have recovered from TGE are carriers of the virus and
can spread TGE to uninfected swine for many weeks. TGE does not cause
human disease.
Clinical Diagnosis
The stool of the normal pig should be firm
and well-formed. When a normal show pig is on free-choice feed and
water, the stool tends to loosen to the consistency of a cow patty as
feed consumption increases. Feed restriction reduces the amount of stool
and tends to be constipating, particularly if water also is restricted.
When
feces are totally liquid with no solid form, diarrhea is occurring. A
pig with diarrhea caused by infectious agents and/or parasites usually
has a reduced appetite or is anorexic, but is still drinking. Vomiting
can occur at the start or during diarrheal disease. Weight loss
accompanies diarrheal disease and is usually obvious because show pigs
are weighed frequently to monitor weight gain. It is common for show
pigs to be affected with more than one diarrheal disease condition and
have dramatic weight loss.
As
soon as the pig develops diarrhea, the cause or causes need to be
determined. Loose stool or diarrhea caused by diet usually does not
result in weight loss. Restricting feed intake, reducing the protein
content of a feed by about 4% and/or substituting rolled or crimped oats
or oatmeal as 25% to 50% of the ration usually cures dietary induced
diarrhea.
Consult a veterinarian to diagnose infectious and/or parasite-caused
diarrheal disease because death is often a result of undiagnosed,
chronic diarrheal disease in show pigs.
TGE
is the least important of the diarrheal diseases because it is
self-limiting and almost never causes death loss in older pigs. Electron
microscopic examination of feces at a diagnostic laboratory is the most
rapid way to diagnose TGE. For other diseases, a veterinarian typically
does the following:
-
Cultures the feces for salmonella
infection,
-
Starts the pig on a water medication of
lincomycin (Lincomix®*) or tiamulin (Denagard®*) plus electrolytes as
a treatment for swine dysentery, and
-
Performs a fecal flotation to check for
microscopic whipworm eggs.
If
Escherichia coli is isolated during fecal culture for
salmonella, it is probably not important as a cause of diarrhea in show
pigs weighing above 40 pounds. If sensitivity testing of the E. coli
isolate demonstrates that most antibiotics tested in the laboratory will
kill it, then the veterinarian has evidence that this E. coli is
normal gut flora and not a pathogen.
During microscopic examination for whipworms, Coccidia oocysts
(eggs) and/or Balantidium coli protozoan ciliates might be
observed. Coccidiosis usually is considered to be a self-limiting and
co-occurring infection that needs no treatment to improve. The B.
coli are commensals, benefitting from their relationship with
another infectious agent. Neither of these two organisms are the primary
cause of diarrhea.
Postmortem Diagnosis
If a show pig with signs of diarrheal
disease dies, a necropsy can be performed by a veterinarian to determine
the cause or causes. Rapid decomposition of organs and tissues,
especially in hot weather, can make the animal unsuitable for testing.
Place the deceased pig in a plastic bag and pack in generous amounts of
ice in an insulated container to prolong preservation until veterinary
examination. Do not freeze the carcass because thawing destroys cellular
structure and makes microscopic disease diagnosis impossible. If the
animal is well preserved, the veterinarian can either send the entire
animal carcass to a diagnostic laboratory or perform a necropsy and
submit tissues to a diagnostic lab for further tests to confirm a
presumptive diagnosis. Other show pigs on the same premises could
benefit by early disease recognition and treatment if a diagnosis is
confirmed on the deceased animal.
Treatment and Control
Veterinarians use no specific treatment for
TGE but prescribe electrolytes to minimize dehydration and possibly
antibiotics to control secondary bacterial infection.
If
salmonella diarrhea is diagnosed via culture, a veterinarian will choose
the antibiotic that is the most effective and has the shortest
withdrawal time. Typically, salmonella that cause diarrhea in show pigs
are resistant to the majority of antibiotics; this is why laboratory
culture and sensitivity testing are so important.
If
pigs, treated for possible swine dysentery with lincomycin (Lincomix®*)
or tiamulin (Denagard®*) plus electrolytes in the water, pass a firmer
stool in several days, this indicates to the veterinarian that swine
dysentery is at least one cause of diarrhea. Medicated water treatment
is continued for five days after improvement with lincomycin or for a
total of five days of therapy with tiamulin. At the end of the water
treatment, recovering animals should be continuously fed medicated feed
containing lincomycin (40 grams/ton, no withdrawal time) or tiamulin (35
grams/ton, two-day withdrawal time) to prevent swine dysentery from
recurring.
Fenbendazole (Safe-Guard®*) given orally for three days is an excellent
parasiticide for whipworm adults and most developing larval stages;
deworming should be repeated in a month. Dichlorvos (Atgard®* C) is
another commonly used dewormer for whipworms. Ivermectin (Ivomec®*) and
doramectin (Dectomax®*) are excellent injectable dewormers and also kill
lice and mange, but have variable effectiveness against whipworms.
Prevention
Prevention of diarrheal diseases, and
diseases in general, starts with preparation before producing or
purchasing one or more show pigs. Show pigs that are farrowed at one
location, never exposed to other swine, and fed at that location until
exhibition should be very healthy. When purchasing, it is best to
buy show pigs directly from the farm of origin and from only one
producer with a history and track record of excellent herd health. It is
acceptable to house these pigs together in one pen (unless they are
fighting too much or need to be fed different rations). If show pigs are
purchased directly from several farms, it is advisable to keep
pigs from each farm in separate pens and not in fence-line contact for
60 days. Consider these separate isolation pens as totally different
locations and wash and disinfect boots, equipment, etc., before going
from one pen to another. In fact, it could be practical to keep these
pigs isolated for the entire feeding period prior to exhibition.
If
pigs are shown multiple times during a season, after each return to the
farm isolate them in their own pen. Do not expose other swine (such as
breeding stock) on the farm to the many disease-causing organisms that
these exhibited swine may have encountered. If show pigs are purchased
at a sale that is not at the farm of origin or pigs are bought directly
from multiple farms, mixed on a trailer, and transported to a location
for distribution to buyers, they potentially are exposed to many
disease-causing organisms. The greater the exposure, the greater the
likelihood of disease problems. Treating pigs with an antibiotic to
compensate for poor health management is usually ineffective. Also,
highly effective vaccines are not available for many diseases. As a
general rule, it is much easier to prevent swine diseases using good
management practices than to successfully treat or vaccinate against
disease.
Diet-induced diarrheal disease can be prevented by not overfeeding
protein and other ingredients such as fat. Gradually switch the pig from
one type ration to another. Make sure the pig finds the water source
because water intake is important for adequate feed consumption. A lack
of water for a couple of days followed by overconsumption of water can
be fatal; this condition is called salt toxicity or water deprivation.
Pigs that are “held back” or limit fed to prevent excessive weight gain
should always have access to plenty of water.
Whipworms can be prevented by routinely deworming healthy pigs with
an effective product (Safe-Guard®* or Atgard®* C) at least once during
the feeding period and by housing them on clean dirt, sand, or pasture
or uncontaminated concrete floors. Routine deworming in show pigs is
commonly performed during the first week after purchase at about 8 to 10
weeks of age or 50 pounds, and then about a month later. Another option
is to take a fresh stool sample to a veterinarian for fecal flotation
and microscopic examination for whipworm eggs. It takes a minimum of 42
days from the time a pig is infected until adults are present and eggs
are passed in feces. This means fecal examination for whipworm eggs
before six weeks of age is not necessary. Also, whipworm adults are
intermittent egg layers so one negative fecal flotation does not
completely rule out whipworm infection.
Swine dysentery is preventable by obtaining pigs directly from a
farm that is free of swine dysentery and minimizing exposure to other
swine or feces-contaminated premises, trailers, and equipment such as
scales. Absence of diarrhea containing blood and mucus, excellent growth
performance, and no significant death loss in pigs from weaning through
market weight are evidence of freedom from swine dysentery in a herd. In
reality, the credibility of swine dysentery-free status is based on each
breeder’s reputation.
The
following medications are included in show swine rations by feed
manufacturers to prevent swine dysentery:
-
Lincomix®*—100 or 200 grams/ton for 30
days, then 40 grams/ton continuously (0 withdrawal days before
slaughter at 40 grams/ton; six-day withdrawal before slaughter at 100
or 200 grams/ton), or
-
Denagard®*—200 grams/ton for 30 days, then
35 grams/ton continuously (two-day withdrawal before slaughter at 35
grams/ton; seven-day withdrawal at 200 grams/ton).
An
alternative and less expensive strategy is to use the continuous lower
levels of Lincomix®* (40 grams/ton) or Denagard®* (35 grams/ton) in feed
to minimize sickness if pigs are infected.
Mecadox is another alternative feed medication to prevent swine
dysentery, but it has an extremely long withdrawal time.
It
is best to take show pigs off of all medication (even 0-withdrawal
medication) at least 24 hours before exhibition.
The
best prevention for salmonellosis is to obtain the healthiest
pigs possible and to manage pigs to reduce stress and maintain good
sanitation practices. It is not a good practice to put antibiotics in
the feed to prevent salmonellosis because antibiotic resistance is very
common with salmonella species (however, Mecadox®*—50 grams/ton fed
continuously, 42-day withdrawal before slaughter—is approved for the
control of salmonellosis caused by S. choleraesuis). Vaccines are
available for S. typhimurium and S. choleraesuis,
but these have not been widely used in show swine. There are numerous
sources of salmonella, and host-adapted and nonhost-adapted salmonella
can cause human disease if the organisms are ingested. Animal and human
salmonellosis can be prevented by proper sanitary measures such as
hand-washing, proper livestock and pen management, bedding changes,
premise cleaning and disinfection, pasture rotation, rodent control, and
proper food preparation and cooking.
TGE
can be prevented by not exposing swine to sources of the virus. Vaccines
are available that control the effects of disease; they do not prevent
infection with TGE.
Summary
Along with pneumonia and lameness, chronic
diarrheal disease is one of the three most important disease problems in
show swine from five weeks of age (about 25 pounds) through the last day
of exhibition. Prompt diagnosis and treatment are important because
chronic, undiagnosed diarrhea frequently results in death.
A
veterinarian should be consulted to assist in the diagnosis, treatment,
and prevention of this and other conditions.
Refer to Texas Agricultural Extension Service fact sheet L-5203, “Swine
Pneumonia,” for information on swine respiratory disease. The Pork
Industry Handbook fact sheet PIH 36, “Swine Arthritis,” contains
information about lameness in swine. The Pork Industry Handbook
is available from Purdue University Cooperative Extension Service,
765-494-6794 (phone).
For
more information:
Selected articles in Proceedings of the American Association of Swine
Practitioners. 1995-1999.
Selected articles in Proceedings of Allen D. Leman Swine Conference,
1997 and 1998.
Stewart, B.S., Stromberg, B.E. and Lawhorn, D.B., “Internal Parasites of
Swine,” PIH - 44, Pork Industry Handbook, Purdue University, West
Lafeyette, Indiana, 1993.
Harris, D.L., Glock, R.D., Joens, L., et al, “Swine Dysentery,” PIH -
56, Pork Industry Handbook, Purdue University, West Lafeyette,
Indiana, 1993.
Becker, H. N., Meyerholz, G.W. and Gaskin, G.W., “Selection and Use of
Disinfectants in Disease Prevention,” PIH - 80, Pork Industry
Handbook, Purdue University, West Lafayette, Indiana, 1990.
Sulaiman, I.M., Xiao, L., Yang, C., et al, “Differentiating Human from
Animal: Isolates of Cryptosporidium parvum,” Emerging
Infectious Diseases, Vol. 4, No. 4, 1998.
Feed Additive Compendium, The Miller Publishing Company, Minnetonka,
Minnesota, 1998.
Veterinary Pharmaceuticals and Biologicals, 9th Edition, Veterinary
Medicine Publishing Company, Lenexa, Kansas, 1995/1996.
The
information given herein is for educational purposes only. Reference to
commercial products or trade names is made with the understanding that
no discrimination is intended and no endorsement by the Texas
Agricultural Extension Service is implied.
The
USER is always responsible for the effects of products administered.
Always read and follow carefully the instructions on the product label.
*Not trademarks of ADM